Neurology
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P77: NADPH Oxidase Type 4 Inhibits Immune Cell Trafficking into The Central Nervous System During Neuroinflammation
Transendothelial trafficking of immune cells into the central nervous system (CNS) and disruption of the blood brain barrier (BBB) are pathophysiological hallmarks of neuroinflammatory disorders like multiple sclerosis (MS). Accumulating evidence suggest that oxidative stress plays a major role in the pathogenesis of MS, whereas a specific influence of oxidative stress on BBB dysfunction in MS ...
متن کاملP38: The Immunoregulatory Effect of Cyclic Dinucleotides on Human Immune Cells
In multiple sclerosis (MS) beneficial effects have been assigned to the interferon (IFN)-I subclass IFN-ß, making its administration a first-line disease-modifying treatment in MS. IFN-I responses can be induced by cyclic-dinucleotide (CDN) triggered activation of Stimulator-of-interferon-genes (STING) and have essential immunomodulatory effects. A beneficial effect of STING activation on...
متن کاملSchool News: Report of World Congresses on Epilepsy and Neurology
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متن کاملP27: KCNK2 and Adhesion Molecules in an in-Vitro Blood Brain Barrier Model
Two-pore domain potassium channels, like KCNK2, are known to play an important role in inflammatory diseases such as multiple sclerosis (MS). Upregulation of cellular adhesion molecules in mouse brain microvascular endothelial cells (MBMECs) of Kcnk2-/- mice resulted in elevated leukocyte trafficking into the central nervous system under inflammatory conditions. The current project aims to gain...
متن کاملThe Effects of Citicoline on Cerebrovascular Hemodynamic Status in Ischemic Stroke Patients
Introduction: Some recent studies have shown that citicoline improves clinical symptoms in patients with stroke. Citicoline's mechanism of action in improving the clinical symptoms is not recognized yet. The aim of this study was to evaluate the cerebrovascular hemodynamic status in patients with ischemic stroke treated with citicoline compared with the control group. <st...
متن کاملAcute Finger Paralysis: A Case Report of Cortical Ischemic Stroke
Somatotopic distribution of motor cortex and sensory fibers is theoretically fully understood. We present a case of stroke, mimicking peripheral palsy, with finger paralysis attributed to cortical lesion. The patient’s brain MRI may be useful to further understand the somatotopic representation of fingers in precentral and postcentral gyrus.
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